2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W768295
    D-Lactose monohydrate-13C6 98%
    D-Lactose monohydrate-13C6 is the 13C-labeled D-Lactose (hydrate) (HY-W115740). D-Lactose monohydrate is a type of lactose. D-Lactose is composed of D-galactose and D-glucose. D-Lactose monohydrate can be used as sweetener or excipient.
    D-Lactose monohydrate-13C6
  • HY-W768296
    D-Lactose monohydrate-13C12 98%
    D-Lactose monohydrate-13C12 is the 13C-labeled D-Lactose (hydrate) (HY-W115740). D-Lactose monohydrate is a type of lactose. D-Lactose is composed of D-galactose and D-glucose. D-Lactose monohydrate can be used as sweetener or excipient.
    D-Lactose monohydrate-13C12
  • HY-W768302
    D-Lyxose-13C5 98%
    D-Lyxose-13C5 is the 13C-labeled D-Lyxose. D-Lyxose is an?endogenous metabolite.
    D-Lyxose-13C5
  • HY-W768934
    L-Gulono-1,4-lactone-13C6 98%
    L-Gulono-1,4-lactone-13C6 (L-Gulonolactone-13C6) is the 13C-labeled L-Gulono-1,4-lactone (HY-W016628). L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.
    L-Gulono-1,4-lactone-13C6
  • HY-W769079
    N-Isovaleroylglycine-13C2,15N 98%
    N-Isovaleroylglycine-13C2,15N is the 13C- and 15N-labeled N-Isovaleroylglycine (HY-W015464). N-Isovaleroylglycine is an acyl glycine and could be used as a biomarker for the predispositon for weight gain and obesity.
    N-Isovaleroylglycine-13C2,15N
  • HY-W769171
    Suberylglycine-13C2,15N 98%
    Suberylglycine-13C2,15N is the 13C- and 15N-labeled Suberylglycine (HY-113367). Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid.
    Suberylglycine-13C2,15N
  • HY-W769935
    5-POHSA 2161370-68-7 98%
    5-POHSA, a fatty acid esters of hydroxy fatty acid (FAHFA), potentiates glucose transport.
    5-POHSA
  • HY-W769991
    Lactate sodium (60% in water)-13C2 1173021-18-5 98%
    Lactate sodium (60% in water)-13C2 (Lactic acid sodium-13C2) is the 13C-labeled Lactate sodium (60% in water) (HY-B2227B). Lactate (60% in water) (Lactic acid) sodium is the product of glycogenolysis and glycolysis. Lactate sodium (60% in water) is an organic salt that is mainly used as a buffer and pH adjuster for injection solutions. Lactate sodium (60% in water) can be metabolized by the body into sodium bicarbonate, which in turn acts to increase the pH of the blood. Lactate sodium (60% in water) is used to improve metabolic acidosis and hypovolemic states. In terms of pharmaceutical preparations, Lactate sodium (60% in water) is often used in combination with sodium chloride, glucose, etc. to form normal saline or compound liquid intravenous injection. Lactate sodium (60% in water) also has antimicrobial activity, which can be used as a food preservative.
    Lactate sodium (60% in water)-13C2
  • HY-W770204
    1-Palmitoyl-2-linoleoyl-rac-glycerol-d5 98%
    1-Palmitoyl-2-linoleoyl-rac-glycerol-d5 is the deuterium labeled 1-Palmitoyl-2-linoleoyl-rac-glycerol (HY-W740434). 1-Palmitoyl-2-linoleoyl-rac-glycerol is a diacylglycerol that contains Palmitic acid (HY-N0830).
    1-Palmitoyl-2-linoleoyl-rac-glycerol-d5
  • HY-W770914
    Stearoyl-L-carnitine chloride-13C3 98%
    Stearoyl-L-carnitine chloride-13C3 is the 13C-labeled Stearoyl-L-carnitine chloride (HY-130466). Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2. Stearoyl-L-carnitine chloride inhibits glycine responses by 16.8% at concentrations up 3 μM.
    Stearoyl-L-carnitine chloride-13C3
  • HY-W771036
    Argininic acid-13C6 98%
    Argininic acid-13C6 (L-Argininic Acid-13C6) is the 13C-labeled Argininic acid (HY-113079). Argininic acid is an α-amino acid that is used in the biosynthesis of proteins.
    Argininic acid-13C6
  • HY-W771063
    8-Aminoguanine-13C2,15N 98%
    8-Aminoguanine-13C2,15N is the 13C- and 15N-labeled 8-Aminoguanine (HY-139037). 8-Aminoguanine is a endogenous purine. 8-Aminoguanine inhibits PNPase (purine nucleoside phosphorylase). 8-Aminoguanine induces diuresis/natriuresis/glucosuria.
    8-Aminoguanine-13C2,15N
  • HY-W773779
    GSK3-IN-9 748145-12-2 98%
    GSK3-IN-9 (Compound 0713) is a selective glycogen synthase kinase 3 (GSK3) inhibitor. GSK3-IN-9 Fragile X syndrome, attention deficit hyperactivity disorder (ADHD), childhood seizure, intellectual disability, diabetes, acute myeloid leukemia (AML), autism, and psychiatric disorder.
    GSK3-IN-9
  • HY-W777002
    Famotidine-13C3 1185241-48-8 98%
    Famotidine-13C3 (MK-208-13C3) is the 13C-labeled Famotidine (HY-B0377). Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
    Famotidine-13C3
  • HY-W777154
    Zoledronic acid-15N2,13C2 1189694-79-8 98%
    Zoledronic acid-15N2,13C2 (CGP 42446-15N2,13C2) is the 13C- and 15N-labeled Zoledronic Acid (HY-13777). Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects.
    Zoledronic acid-15N2,13C2
  • HY-W777434
    Mitiglinide calcium hydrate-d8 98%
    Mitiglinide (calcium hydrate)-d8 is the deuterium labeled Mitiglinide (calcium hydrate) (HY-B0682A). Mitiglinide calcium hydrate (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide Calcium hydrate can be used for the research of type 2 diabetes.
    Mitiglinide calcium hydrate-d8
  • HY-W777477
    Homovanillic Acid-13C6 1185016-45-8 98%
    Homovanillic Acid-13C6 (Vanilacetic acid-13C6) is the 13C-labeled Homovanillic acid (HY-N0384). Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
    Homovanillic Acid-13C6
  • HY-W777762
    Dodecanedioic Acid-13C12 1173019-20-9 98%
    Dodecanedioic Acid-13C12 is the 13C-labeled Dodecanedioic acid (HY-W012241). Dodecanedioic acid is an orally active straight-chain dicarboxylic acid. As an alternative energy substrate between lipids and carbohydrates, Dodecanedioic acid can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion. Dodecanedioic acid also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus.
    Dodecanedioic Acid-13C12
  • HY-W777871
    rac-1-Palmitoyl-2-linoleoyl-3-chloropropanediol-d5 1246833-66-8 98%
    rac-1-Palmitoyl-2-linoleoyl-3-chloropropanediol-d5 is the deuterium labeled 1-Palmitoyl-2-linoleoyl-3-chloropropanediol (HY-W777870). 1-Palmitoyl-2-linoleoyl-3-chloropropanediol is an ester product.
    rac-1-Palmitoyl-2-linoleoyl-3-chloropropanediol-d5
  • HY-W778692
    1-Linoleoyl Glycerol-d5 1795137-84-6 98%
    1-Linoleoyl Glycerol-d5 (1-Linoleoyl-rac-glycerol-d5; 1-Monolinolein-d5) is the deuterium labeled 1-Linoleoyl Glycerol (HY-111346). 1-Linoleoyl glycerol is a LpPLA2 inhibitor. 1-Linoleoyl glycerol acts as a precursor for synthesizing various functional lipids, such as phospholipids. 1-Linoleoyl glycerol mitigates inflammation induced by Apolipoprotein CIII (reduction of IL-6).
    1-Linoleoyl Glycerol-d5
Cat. No. Product Name / Synonyms Application Reactivity